paramjani21/feynman/proteinmpnn

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Design protein sequences from fixed backbone structures with ProteinMPNN-style workflows. Use when a task asks for backbone-conditioned sequence design, mutation suggestions, fixed residues, or design filtering.

Install

npx vskill@latest install paramjani21/feynman/proteinmpnn

SKILL.md

ProteinMPNN

Use this skill for fixed-backbone protein sequence design.

Workflow:

  1. Record input structure, chain ids, designed positions, fixed residues, tied positions, symmetry, and design objective.
  2. Verify the local or remote execution route before running.
  3. Save PDB/mmCIF inputs, design masks, command, seeds, model version, FASTA outputs, and score tables.
  4. Filter designs by constraints, diversity, motifs, structure prediction, conservation, and assay-ready feasibility.
  5. Attach provenance and a verification plan before recommending candidates.

Treat generated sequences as candidates that require structural and experimental validation.

Security

  • Security scanPassed, 95 of 100Pattern checks on the skill's files.
  • Model reviewPassed

Quality evaluation

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Works with

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